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Nutrient ingestion, protein intake, and sex, but not age, affect the albumin synthesis rate in humans.
- Source :
- Journal of Nutrition; Jul2007, Vol. 137 Issue 7, p1734-1740, 7p, 1 Chart
- Publication Year :
- 2007
-
Abstract
- The aim of this study was to assess the effects of nutrient ingestion, dietary protein intake, age, and sex on the fractional synthesis rate (FSR) of albumin. Thirty-six healthy free-living individuals (8 females and 10 males aged 21-43 y and 9 females and 9 males aged 63-79 y) completed three 18-d periods of controlled feeding with protein intakes of 125% (P125, 1.00 g protein x kg(-1) x d(-1)), 94% (P94, 0.75 g protein x kg(-1) x d(-1)), and 63% (P63, 0.50 g protein x kg(-1) x d(-1)) of the recommended dietary allowance. On d 12 of each trial, postabsorptive (PA) serum albumin concentration was determined and PA and postprandial (PP) albumin FSR were estimated from the rate of l-[1- 13C] leucine incorporation into plasma albumin during an 8-h infusion. There were no age-related differences in PA and PP albumin FSR. Albumin FSR was higher PP than PA (P < 0.0001), and the increase in albumin FSR from PA to PP was smaller as dietary protein intake decreased from P125 to P94 and P63 (P < 0.05). Independent of protein intake, males had a higher albumin FSR (P < 0.05) and a greater increase in albumin FSR with feeding (P < 0.05). There was no age or dietary protein effect on serum albumin concentrations, but males had higher albumin concentrations than females (P < 0.0001). These results show that older persons are responsive to nutrient ingestion and dietary protein-related changes in albumin FSR. The greater albumin synthesis rate in males might contribute to a higher albumin concentration set point. [ABSTRACT FROM AUTHOR]
- Subjects :
- INGESTION
ABSORPTION (Physiology)
NUTRIENT interactions
LOW-protein diet
SERUM albumin
ALBUMINS
BLOOD plasma
BLOOD proteins
LEUCINE
AGING
COMPARATIVE studies
DIET
ENERGY metabolism
HUMAN reproduction
RESEARCH methodology
MEDICAL cooperation
DIETARY proteins
RESEARCH
EVALUATION research
RANDOMIZED controlled trials
Subjects
Details
- Language :
- English
- ISSN :
- 00223166
- Volume :
- 137
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 25586571
- Full Text :
- https://doi.org/10.1093/jn/137.7.1734