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Subtype-Specific Pharmacological Properties of the Melanocortin Receptors in Chicken.
- Source :
- Annals of the New York Academy of Sciences; 2005, Vol. 1040 Issue 1, p378-380, 3p
- Publication Year :
- 2005
-
Abstract
- The melanocortin (MC) receptors belong to the family of G-proteincoupled receptors and have five subtypes (MC1-5) in mammals and chicken. We have expressed the chicken MC1-5 (cMC1-5) receptors and seven allelic variants of the cMC1 receptor and performed pharmacological characterization of these receptors. Three variants of the cMC1 receptor, all sharing a Glu to Lys mutation in position 92, are associated with dark feather coloration, and these were pharmacologically described as constitutively active. The pharmacological characterization of the cMC1-5 receptors provides insight of how this receptor family has evolved and useful information for the use of chicken in physiological experiments. [ABSTRACT FROM AUTHOR]
- Subjects :
- G proteins
MAMMALS
MEMBRANE proteins
POULTRY as laboratory animals
PHARMACOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00778923
- Volume :
- 1040
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25254091
- Full Text :
- https://doi.org/10.1196/annals.1327.067