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Viral Factors Associated with Cytokine Expression During HCVHIV Co-Infection.
- Source :
- Journal of Interferon & Cytokine Research; Apr2007, Vol. 27 Issue 4, p263-270, 1p
- Publication Year :
- 2007
-
Abstract
- Co-infection with human immunodeficiency virus (HIV) is associated with reduced hepatitis C virus (HCV) treatment response and accelerated HCV disease. Cytokines, as mediators of immune responses, inflammation, and fibrogenesis, may underlie important differences in HCV pathogenesis during HIV co-infection. We previously found that serum interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α) increased after HCV therapy with interferon (IFN) in HCVHIV co-infected patients; however, cytokine levels were not predictive of HCV therapeutic response. Here, we examined viral factors associated with expression of IL-8, TNF-α, and transforming growth factor-β1 (TGF-β1) in uninfected, HCV mono-infected, HIV mono-infected, and HCVHIV co-infected persons. HIV co-infection was associated with decreased IL-8 detection but not TNF-αdetection. A significant interaction effect demonstrated that HIV infection was associated with elevated TGF-β1 in HCV-positive individuals but not in HCV-negative individuals. The induction of a sustained profibrotic signal, such as TGF-β1, by HIV may cause accelerated liver fibrosis during HCVHIV co-infection and may hinder the host's ability to mount an effective HCV-specific immune response. Further studies are warranted to identify noninvasive markers of liver disease for the clinical management of HCV disease, particularly when liver biopsies have not been performed or are contraindicated. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV infections
HIV
DISEASES
LIVER biopsy
Subjects
Details
- Language :
- English
- ISSN :
- 10799907
- Volume :
- 27
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Interferon & Cytokine Research
- Publication Type :
- Academic Journal
- Accession number :
- 24997353