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Use of etanercept for psoriatic arthritis in the dermatology clinic: The Experience Diagnosing, Understanding Care, and Treatment with Etanercept (EDUCATE) study.
- Source :
- Journal of Dermatological Treatment; Dec2006, Vol. 17 Issue 6, p343-352, 10p, 1 Diagram, 1 Chart, 1 Graph
- Publication Year :
- 2006
-
Abstract
- Objective: To assess the efficacy and tolerability of etanercept to treat psoriatic arthritis. Materials and methods: A total of 1122 patients who had active psoriatic arthritis were enrolled in a Phase 4, non-randomized, open-label, single-arm, 24-week study. These patients had clinically stable, plaque psoriasis involving ≥10% body surface area and joint disease (either ≥two swollen and ≥two tender/painful joints for ≥3 months, or ≥one joint with sacroiliitis or spondylitis). They received etanercept therapy 50 mg subcutaneously once weekly for 24 weeks. Results: After 24 weeks of treatment, 865 patients (77.1%; 95% CI: 74.64-79.55%) achieved a 'mild or better' score on the physician global assessment of psoriasis and were improved from baseline. Mean improvement in body surface area involvement was 16.9 percentage points (15.89-17.91). Patient global assessment of psoriasis, joint pain, and joint disease scores were improved by means of 2.2 (2.15-2.34), 2.7 (2.53-2.84), and 1.5 (1.39-1.55), respectively. Thirty-five patients (3.1%) experienced at least one serious adverse event. No patient died during the study. Conclusions: These results support the effectiveness and tolerability of etanercept treatment in patients with psoriatic arthritis being treated at dermatology clinics. [ABSTRACT FROM AUTHOR]
- Subjects :
- EFALIZUMAB
PSORIATIC arthritis
PSORIASIS
CLINICAL trials
DRUG efficacy
Subjects
Details
- Language :
- English
- ISSN :
- 09546634
- Volume :
- 17
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Dermatological Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 24904785
- Full Text :
- https://doi.org/10.1080/09546630600967166