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Oral olanzapine versus oral haloperidol in the maintenance treatment of schizophrenia and related psychoses.
- Source :
- British Journal of Psychiatry; Jun98, Vol. 172, p499-505, 7p, 2 Charts, 2 Graphs
- Publication Year :
- 1998
-
Abstract
- <bold>Background: </bold>Three studies compared olanzapine and haloperidol given orally in maintenance therapy for schizophrenia and related psychoses.<bold>Method: </bold>Data were from double-blind extensions of acute studies. The subjects met criteria for schizophrenia, schizophreniform disorder or schizoaffective disorder. Subjects had responded to acute therapy (Brief Psychiatric Rating Scale total score decreased > or = 40% from baseline (Studies 1, 2, and 3) or was < or = 18 (Studies 1 and 2)) and were out-patients at their last acute phase visit. Relapse was defined as hospitalisation for psychopathology. Subjects treated with olanzapine in the three studies were pooled to form the olanzapine group and subjects treated with haloperidol were pooled to form the haloperidol group.<bold>Results: </bold>Olanzapine-treated subjects experienced less relapse (P = 0.034). The Kaplan-Meier estimated one-year risk of relapse was 19.7% with olanzapine and 28% with haloperidol.<bold>Conclusion: </bold>Olanzapine was superior to haloperidol in the maintenance therapy of schizophrenia and related psychoses.<bold>Declaration Of Interest: </bold>This work was sponsored by Eli Lilly and Company. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG efficacy
ORAL drug administration
ANTIPSYCHOTIC agents
OLANZAPINE
THERAPEUTICS
SCHIZOPHRENIA
PSYCHOSES
SCHIZOAFFECTIVE disorders
DRUG therapy for psychoses
DRUG therapy for schizophrenia
BENZODIAZEPINES
CLINICAL trials
COMPARATIVE studies
LIFE expectancy
RESEARCH methodology
MEDICAL cooperation
RESEARCH
STATISTICS
SURVIVAL analysis (Biometry)
TRANQUILIZING drugs
DISEASE relapse
EVALUATION research
TREATMENT effectiveness
BLIND experiment
HALOPERIDOL
Subjects
Details
- Language :
- English
- ISSN :
- 00071250
- Volume :
- 172
- Database :
- Complementary Index
- Journal :
- British Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 24882399
- Full Text :
- https://doi.org/10.1192/bjp.172.6.499