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Correlation of the CD4+CD25high T-regulatory cells in recipients and their corresponding donors to acute GVHD.
- Source :
- Transplant International; May2007, Vol. 20 Issue 5, p440-446, 7p, 3 Charts, 3 Graphs
- Publication Year :
- 2007
-
Abstract
- Graft-versus-host disease continues to be a major life-threatening complication after allogeneic hematopoietic stem cells transplantation (aHSCT). The relationship of acute GVHD (aGVHD) with the levels of peripheral CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells in patients after aHSCT and in their corresponding donors is not fully investigated. We examined the levels of CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells in patients after aHSCT and in their corresponding donors, and analyzed the relationship of CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells to the incidence and prognosis of aGVHD. The recipients with normal or high CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells (three of eight, 37.5%) had no or mild aGVHD (grade I), and all survived during the follow-up period. In striking contrast, the recipients with lower or no CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells suffered from greater than grade II aGVHD (four of four, 100%), and all died within 1-year post-aHSCT. Moreover, the number of CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells in recipients correlated significantly with that of their corresponding donors. The CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells from the recipients and their corresponding donors expressed high levels of Foxp3, and effectively suppressed the proliferation of CD4<superscript>+</superscript>CD25<superscript>−</superscript> responder T cells. This study suggests that human Treg cells may play an important role in aGVHD, as has been seen in murine models. The levels of peripheral CD4<superscript>+</superscript>CD25<superscript>high</superscript> T cells in recipients and donors could be helpful for predicting of the onset and outcome of aGVHD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09340874
- Volume :
- 20
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Transplant International
- Publication Type :
- Academic Journal
- Accession number :
- 24541697
- Full Text :
- https://doi.org/10.1111/j.1432-2277.2007.00462.x