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A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.
- Source :
- Leukemia (08876924); Apr2007, Vol. 21 Issue 4, p647-650, 4p, 2 Graphs
- Publication Year :
- 2007
-
Abstract
- Alterations of the retinoic acid receptor (RAR)alpha locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARalpha chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARbeta and RARgamma), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARalpha locus in leukemia patients must occur--rather than through functional differences among the various RAR isoforms-as the consequence of the nuclear architecture of the different RAR loci. [ABSTRACT FROM AUTHOR]
- Subjects :
- RETINOIDS
RECEPTOR antibodies
ONCOGENIC DNA viruses
LEUKEMIA
CHROMOSOMAL translocation
GENETIC vectors
GENE transfection
PATIENTS
ANIMAL experimentation
CELL lines
CELL receptors
CHROMOSOME abnormalities
COMPARATIVE studies
GENETIC techniques
RESEARCH methodology
MEDICAL cooperation
MICE
PROTEINS
RESEARCH
RNA
EVALUATION research
ACUTE promyelocytic leukemia
Subjects
Details
- Language :
- English
- ISSN :
- 08876924
- Volume :
- 21
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Leukemia (08876924)
- Publication Type :
- Academic Journal
- Accession number :
- 24458757
- Full Text :
- https://doi.org/10.1038/sj.leu.2404572