Current uses and future hopes for clinical pharmacology in the management of HIV infection.

The article focuses on the study on pharmacokinetic variability as an important consideration in treatment failure and current approaches to address the problem towards HIV-positive patients. Despite the exposure to most antiretroviral agents and consequently receiving salvage therapy, noticeable number of patients who fail the treatment is growing. Regimens are associated with increased potential for toxicity and serious drug interactions. Reasons of treatment failure is presented.