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Reducing the Dose of Smallpox Vaccine Reduces Vaccine-Associated Morbidity without Reducing Vaccination Success Rates or Immune Responses.
- Source :
- Journal of Infectious Diseases; 3/15/2007, Vol. 195 Issue 6, p826-832, 7p
- Publication Year :
- 2007
-
Abstract
- Background. When the decision was made to prepare for a deliberate release of smallpox, the United States had ~15 million doses of Wyeth Dryvax vaccine, which was known to induce significant morbidity when used undiluted; Sanofi Pasteur, Inc., later identified ~85 million additional doses in storage. Methods. Eleven vaccine-dose groups, each with 30 vaccinia-naive subjects, were given diluted Dryvax vaccine or 1 of 2 lots of Sanofi Pasteur smallpox vaccine and were evaluated for vaccination success rates, morbidity, and immune responses. Results. Estimated doses of 10<subscript>6.6</subscript>-10<superscript>8.2</superscript> pfu of virus/mL induced major reactions (or ‘takes’) in 93%-100% of subjects in each dose group. No differences in vaccination take rates, lesion size, erythema, and induration or in serum neutralizing-antibody response were detected between the groups. However, systemic reactogenicity and missed activities were significantly lower for the vaccine groups given doses of 10<superscript>6.6</superscript>-10<superscript>7.2</superscript> pfu/mL than for those given doses of 10<superscript>7.6</superscript>-10<superscript>8.2</superscript> pfu/mL. Conclusions. These findings support the use of a higher dilution of Wyeth Dryvax vaccine and Sanofi Pasteur smallpox vaccine, given that the resulting morbidity should be significantly lower without loss of vaccine effectiveness. A plan for use of higher dilutions would create an enormous stockpile of vaccine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 195
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 24092531
- Full Text :
- https://doi.org/10.1086/511828