Lack of association of the pregnane X receptor (PXR/ NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis.

The article discusses the lack of association of the pregnane X receptor gene with inflammatory bowel disease determined through a parallel allelic association study and gene wide haplotype analysis. According to sources, dysregulation of this gene may influence intestinal barrier defence and susceptibility to inflammatory bowel disease. Thus, a critical re-evaluation of the allelic variants of the gene as determinants of disease susceptibility and phenotype in the Scottish population.