Geroprotection by Glycerol.

Authors :: DEOCARIS, CUSTER C.
SHRESTHA, BHUPAL G.
KRAFT, DAVID C.
YAMASAKI, KAZUHIKO
KAUL, SUNIL C.
RATTAN, SURESH I. S.
WADHWA, RENU
Source :: Annals of the New York Academy of Sciences; 2006, Vol. 1067 Issue 1, p488-492, 5p, 1 Graph
Publication Year :: 2006
Abstract: Chaperones, particularly the heat-shock proteins, are considered as key players in the maintenance of protein homeostasis and are associated with longevity and cellular immortalization. In this study, we investigated the geroprotective activity of the chemical chaperone glycerol. Glycerol showed significant chaperoning activity in refolding heat-denatured luciferase in vivo and in protecting cells from heat stress-induced cytotoxicity. This was accompanied by decrease in p53, an upregulation of a stress chaperone mortalin/mtHsp70, and an increase in proteasome activity in the presence of oxidative stress. [ABSTRACT FROM AUTHOR]