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Phenotypic and Functional Status of Intrahepatic T Cells in Chronic Hepatitis C.
- Source :
- Journal of Infectious Diseases; 10/15/2006, Vol. 194 Issue 8, p1068-1077, 10p
- Publication Year :
- 2006
-
Abstract
- Polychromatic flow-cytometric assays were used to analyze paired intrahepatic and peripheral lymphocyte samples from 37 patients with chronic hepatitis C. Compared with peripheral cells, intrahepatic T cells were selectively enriched with CD45RO<superscript>+</superscript> memory T cells but had a lower percentage of CD4<superscript>+</superscript> T cells expressing the differentiation markers CD27 and CD28. The percentage of intrahepatic CD45RO<superscript>+</superscript> and CD28<superscript>+</superscript> T cells correlated with the degree of liver inflammation, which suggests that memory T cells at relatively early stages of differentiation are directly involved in liver inflammation. Despite their memory phenotype, intrahepatic T cells were defective in proliferation capability, produced less interferon-g in response to stimulation by T cell receptor, and contained less perforin but expressed higher levels of Fas and Fas ligand, compared with their counterparts in peripheral blood. The distinct characteristics of intrahepatic T cells suggest that they play an important role in the immunopathogenesis of chronic hepatitis C. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
HEPATITIS C
CHRONIC diseases
LYMPHOCYTES
CD4 antigen
LIVER cells
INFLAMMATION
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 194
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22408933
- Full Text :
- https://doi.org/10.1086/507681