Modeling, Simulation and Operation Performance of a Simulated Moving Bed for Enantioseparation of Fluoxetine on New β-Cyclodextrin Columns.

A Simulated Moving Bed (SMB) setup, including 8 new β-cyclodextrin columns, was used to achieve the enantioseparation of fluoxetine. The effects of feed concentration and feed flowrate on the operation performance parameters: purity, enrichment, recovery and productivity were studied. A simulation approach was applied to simulate the operation and performance of the simulated counter-current system. The model predicted the performance of the transient and cyclic steady state behaviour to a reasonably good extent. The adsorption isotherm and parameters determined by pulse experiments and moment analysis seem to be adequate in simulating both the transient and steady state behaviour. Generally, this model can provide guidance for designing operation condition of the SMB system. [ABSTRACT FROM AUTHOR]