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Synthesis of new 1H-1,2,4-triazolylcoumarins and their antitumor and anti-HIV activities.
- Source :
- Chemistry of Heterocyclic Compounds; May2006, Vol. 42 Issue 5, p583-590, 8p, 2 Charts
- Publication Year :
- 2006
-
Abstract
- A variety of 7-[(1,5-dialkyl-1H-1,2,4-triazolyl)methoxy(and methyl)]coumarins were synthesized from cycloaddition of 2-(2H-benzopyran-7-yloxy)acetonitrile and 2-(5-methoxy-4-methyl-2H-benzopyran-7-yloxy)acetonitrile, respectively, with various reactive cumulene [InlineMediaObject not available: see fulltext.] intermediates via spontaneous rearrangements. The anticancer (breast, lung, CNS cancers) and antiviral (HIV-1, HIV-2) properties of some compounds were investigated in vitro. 5-Methoxy-4-methyl-7-[(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl)methyl]coumarin showed some inhibition of HIV-1. [ABSTRACT FROM AUTHOR]
- Subjects :
- BENZOPYRANS
ACETONITRILE
TONKA bean
RING formation (Chemistry)
ANTICOAGULANTS
Subjects
Details
- Language :
- English
- ISSN :
- 00093122
- Volume :
- 42
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Chemistry of Heterocyclic Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 22089535
- Full Text :
- https://doi.org/10.1007/s10593-006-0130-2