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Distribution and Genotoxic Effects After Successive Exposure to Different Uranium Oxide Particles Inhaled by Rats.

Authors :
Monleau, Marjorie
De Méo, Michel
Frelon, Sandrine
Paquet, François
Donnadieu-Claraz, Marie
Duménil, Gérard
Chazel, Valérie
Source :
Inhalation Toxicology; Oct2006, Vol. 18 Issue 11, p885-894, 10p
Publication Year :
2006

Abstract

In nuclear fuel cycle facilities, workers may inhale airborne uranium compounds that lead to internal contamination, with various exposure scenarios depending on the workplace. These exposures can be chronic, repeated, or acute, and can involve many different compounds. The effect of uranium after multiple scenarios of exposure is unknown. The aim of this study, therefore, was to investigate the genotoxic and biokinetics consequences of exposure to depleted insoluble uranium dioxide (UO 2 ) by repeated or acute inhalation on subsequent acute inhalation of moderately soluble uranium peroxide (UO 4 ) in rats. The results show that UO 2 repeated preexposure by inhalation increases the genotoxic effects of UO 4 inhalation, assessed by comet assay, in different cell types, when UO 4 exposure alone has no effect. At the same time, the study of UO 4 bioaccumulation showed that the UO 4 biokinetics in the kidneys, gastrointestinal tract, and excreta, but not in the lungs, were slightly modified by previous UO 2 exposures. All these results show that both genotoxic and biokinetics effects of uranium may depend on preexposure and that repeated exposure induces a potentiation effect compared with acute exposure. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08958378
Volume :
18
Issue :
11
Database :
Complementary Index
Journal :
Inhalation Toxicology
Publication Type :
Academic Journal
Accession number :
22088801
Full Text :
https://doi.org/10.1080/08958370600822524