Effect of Spatial Distribution of Magnetic Dipoles on Lamor Frequency Distribution and MR Signal Decay – a Numerical Approach Under Static Dephasing Conditions.

Cells loaded with superparamagnetic iron oxide (SPIO) cause relatively strong magnetic field distortions, implying that field position effects of neighboring SPIO loaded cells have to be accounted for. We treated SPIO loaded cells as magnetic dipoles in a homogeneous magnetic field and computed the 3D frequency distribution and the related signal decay using a numerical approach under static dephasing conditions. The volume fraction of dipoles was kept constant for all simulations. For larger randomly distributed magnetic dipoles we found a non-Lorentzian frequency distribution and a non-monoexponential signal decay whereas, for smaller dipoles, the frequency distribution was more Lorentzian and the signal decay was well fitted monoexponentially. Moreover, based on our numerical and experimental findings, we found the gradient echo signal decay due to a single SPIO labeled cell to be non-monoexponential. The numerical approach provides deeper understanding of how the spatial distribution of SPIO loaded cells affects the MR signal decay. This fact has to be considered for the in vivo quantification of SPIO loaded cells, implying that in tissues with different spatial distributions of identical SPIO concentrations, different signal decays might be observed. [ABSTRACT FROM AUTHOR]