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Contribution of interferon-β to the immune activation induced by double-stranded DNA.
- Source :
- Immunology; Jul2006, Vol. 118 Issue 3, p302-310, 9p, 1 Diagram, 1 Chart, 6 Graphs
- Publication Year :
- 2006
-
Abstract
- Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial/viral factors. Current findings indicate that interferon-β (IFN-β) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond to intracytoplasmic dsDNA by up-regulating IFN-β) expression, a process that reduces host susceptibility to infection. The immune activation induced by dsDNA is independent of MyD88, TRIF and DNA-PKcs, indicating that a Toll-like receptor-independent mechanism underlies the cellular activation mediated by intracytoplasmic dsDNA. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERFERONS
DNA
ANTIGEN presenting cells
DENDRITIC cells
CYTOKINES
CHEMOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 118
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21217490
- Full Text :
- https://doi.org/10.1111/j.1365-2567.2006.02367.x