Cyclo-oxygenase-2 (COX-2) inhibition reduces apoptosis in acute myocardial infarction.

Authors :: Abbate, A.
Limana, F.
Capogrossi, M.
Santini, D.
Biondi-Zoccai, G.
Scarpa, S.
Germani, A.
Straino, S.
Severino, A.
Vasaturo, F.
Campioni, M.
Liuzzo, G.
Crea, F.
Vetrovec, G.
Biasucci, L.
Baldi, A.
Source :: Apoptosis; Jun2006, Vol. 11 Issue 6, p1061-1063, 3p, 2 Graphs
Publication Year :: 2006
Abstract: The article discusses cyclo-oxygenase-2 (COX-2) inhibition that reduces apoptosis in acute myocardial infarction. Cyclo-oxygenase-2 enzyme catalyzes the conversion of arachidonic acid to prostaglandin H2. This study aims to experiment whether COX-2 inhibition will help in preventing apoptosis in cardiomyocytes. A surgical coronary ligation was performed in mice.

Subjects :: CYCLOOXYGENASE 2
CONTACT inhibition
MYOCARDIAL infarction
CORONARY disease
HEART cells
HEART blood-vessels
CORONARY arteries
APOPTOSIS
CELL death

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