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Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy.

Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy.

Authors :
Buytaert, Esther
Callewaert, Geert
Hendrickx, Nico
Scorrano, Luca
Hartmann, Dieter
Missiaen, Ludwig
Vandenheede, Jackie R.
Heirman, Ingeborg
Grooten, Johan
Agostinis, Patrizia
Source :
FASEB Journal; Apr2006, Vol. 20 Issue 6, p756-758, 3p, 2 Diagrams
Publication Year :
2006

Abstract

Presents a study which examined the role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy (PDT). Factor that precedes the onset of intrinsic apoptosis in photodamaged cells; Consequence of PDT-mediated loss of native SERCA2 protein; Execution of photokilling through an autophagic cell death pathway; Conclusions and significance of the study.

Details

Language :
English
ISSN :
08926638
Volume :
20
Issue :
6
Database :
Complementary Index
Journal :
FASEB Journal
Publication Type :
Academic Journal
Accession number :
20862928
Full Text :
https://doi.org/10.1096/fj.05-4305fje