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Hepatitis B Virus-Related Hepatocellular Carcinogenesis and Its Prevention.
- Source :
- Intervirology; Jan/Feb2005, Vol. 48 Issue 1, p29-38, 10p, 2 Diagrams, 2 Charts, 3 Graphs
- Publication Year :
- 2005
-
Abstract
- To elucidate the influence of serum hepatitis B virus (HBV) load on hepatocellular carcinogenesis in cirrhotic patients, HBV-DNA was sequentially measured. In a nested, case-control study using 96 patients without antiviral therapy, high HBV-DNA (≥10<superscript>3.7</superscript> copies/ml) in the last 3 years was significantly associated with carcinogenesis (a patient group without hepatocellular carcinoma (HCC) development; 0/48 vs. a patient group with eventual HCC development; 22/48, p < 0.0001). No patient with a continuously low HBV-DNA for the last 3 years developed HCC. Persistence of high HBV-DNA concentration suggested an increased risk of carcinogenesis. In a retrospective cohort study using 57 patients with interferon therapy, HCC developed in 2 (8.0%) of the 25 patients with HBV-DNA loss, while carcinogenesis was found in 11 (34.4%) of 32 patients without HBV-DNA loss (Fisher’s exact test, p = 0.026). A significant decrease or loss of serum HBV-DNA stops HCC development, and its sequential analysis could be very useful both in the prediction and early detection of small HCC. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- LIVER cancer
HEPATITIS B virus
HEPATITIS viruses
ANTIVIRAL agents
CANCER prevention
Subjects
Details
- Language :
- English
- ISSN :
- 03005526
- Volume :
- 48
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Intervirology
- Publication Type :
- Academic Journal
- Accession number :
- 19918505
- Full Text :
- https://doi.org/10.1159/000082092