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Stroke Units, Tissue Plasminogen Activator, Aspirin and Neuroprotection: Which Stroke Intervention Could Provide the Greatest Community Benefit?
- Source :
- Cerebrovascular Diseases; 2005, Vol. 20 Issue 4, p239-244, 6p, 3 Charts, 2 Graphs
- Publication Year :
- 2005
-
Abstract
- Background: Although a number of acute stroke interventions are of proven efficacy, there is uncertainty about their community benefits. We aimed to assess this within a defined population. Methods: Eligibility for tissue plasminogen activator (tPA), aspirin, stroke unit management and neuroprotection were assessed among incident stroke cases within the community-based North East Melbourne Stroke Incidence Study. Results: Among 306,631 people, there were 645 incident strokes managed in hospital. When eligible patients were extrapolated to the Australian population, for every 1,000 cases, 46 (95% CI 17–69) could have been saved from death or dependency with stroke unit management, 6 (95% CI 1–11) by using aspirin, 11 (95% CI 5–17) or 10 (95% CI 3–16) by using tPA at 3 and 6 h, respectively. Conclusions: Although tPA is the most potent intervention, management in stroke units has the greatest population benefit and should be a priority. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10159770
- Volume :
- 20
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Cerebrovascular Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 19890632
- Full Text :
- https://doi.org/10.1159/000087705