A stop-codon mutation in the BRI gene associated with familial British dementia.

Presents research which identified a 4K protein subunit named ABri from isolated amyloid fibrils associated with familial British dementia (FBD). Symptoms of FBD; FBD's common pathological lesions; Encoding of ABri by the gene BRI; Effects of mutating BRI; Impact of the release of the 34 carboxy-terminal amino acids from the mutated gene; Behavior of antibodies against the amyloid or homologous synthetic peptides; Generation of the ABri peptide.