Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3.

The article discusses the study "Distribution and Dynamics of Lamp1-Containing Endocytic Organelles in Fibroblasts Deficient in BLOC-3," by Ramin Nazarian, Chiara Sabatti et al., published in the "Journal of Cell Science." The researchers developed a method based on image analysis to estimate the extent of organelle clustering in the perinuclear region of cultured cells. The findings suggest that BLOC-3 function is required, directly or indirectly, for optimal attachment of late endocytic organelles to microtubule-dependent motors.