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Long-Term Evolution of Endocrine Disorders and Effect of GH Therapy in 35 Patients with Pituitary Stalk Interruption Syndrome.
- Source :
- Hormone Research; 2005, Vol. 64 Issue 6, p266-273, 8p
- Publication Year :
- 2005
-
Abstract
- We report long-term evolution of endocrine functions and the results of GH treatment in 35 patients (26 male and 9 female) with pituitary stalk interruption. At diagnosis, mean chronological age was 4.8 ± 2.7 years, mean SDS for height -3.1 ± 0.8 with a bone age retardation of 2.3 ± 1.3 years and a mean SDS for growth velocity of -0.5 ± 1.1; 80% presented complete GH deficiency (GHD) and 20% partial GHD; thyroid deficiency was present in 47.1% of children with complete GHD but absent in all partial GHD. Diagnosis was made during the first months of life in only 2 patients while 23% presented with severe neonatal distress; neonatal signs were only observed in the group with pituitary height below 2 mm (45.7% of patients). GHD was isolated in 40.6% of patients below 10 years while multiple hormone deficiencies was consistent at completion of growth in all patients. Height gain was significantly higher in patients who started GH treatment before 4 years (p = 0.002). GH treatment is very effective: in 13 patients, final height was -0.4 ± 1.0, total height gain 3.2 ± 1.2 and distance to target height-0.3 ± 1.6 SDS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03010163
- Volume :
- 64
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Hormone Research
- Publication Type :
- Academic Journal
- Accession number :
- 19031673
- Full Text :
- https://doi.org/10.1159/000089425