The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors :: Maxwell, Patrick H.
Wiesener, Michael S.
Chang, Gin-Wen
Clifford, Steven C.
Vaux, Emma C.
Cockman, Matthew E.
Wykoff, Charles C.
Pugh, Christopher W.
Maher, Eamonn R.
Ratcliffe, Peter J.
Source :: Nature; 5/20/1999, Vol. 399 Issue 6733, p271, 5p, 40 Black and White Photographs, 2 Graphs
Publication Year :: 1999
Abstract: Presents research which demonstrated the role of the von Hippel-Lindau (VHL) tumor suppressor gene product pVHL in hypoxia-inducible factor-1 (HIF-1) regulation. Role of HIF-1 in cellular responses to hypoxia; Degradation of the alpha subunits of HIF; Traits of VHL-defective cells; Effects of re-expression of pVHL; Iron dependency of HIF-1 and pVHL interactions; HIF-1 activation underlying the angiogenic phenotype of VHL-associated tumors; Application to cellular oxygen sensing studies.

Subjects :: TUMOR suppressor genes
HYPOXEMIA
CELLULAR control mechanisms
PROTEINS
PHYSIOLOGY
GENETICS

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