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Interaction of Porphyrin with G-Quadruplex Structures.
- Source :
- Nucleosides, Nucleotides & Nucleic Acids; May2005, Vol. 24 Issue 5-7, p753-756, 4p, 1 Diagram, 1 Chart, 1 Graph
- Publication Year :
- 2005
-
Abstract
- Isothermal titration calorimetry (ITC) is a sensitive technique for probing bimolecular processes and can provide direct information about the binding affinity and stoichiometry and the key thermodynamic parameters involved. ITC has been used to investigate the interaction of the ligand H 2 TMPyP to the two DNA quadruplexes, [d(AGGGT)] 4 and [d(TGGGGT)] 4 . Analysis of the ITC data reveals that porphyrin/quadruplex binding stoichiometry under saturating conditions is 1:2 for [d(AGGGT)] 4 and 2:1 for [d(TGGGGT)] 4 , respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- PORPHYRINS
CALORIMETRY
DEOXYRIBOSE
DNA
NUCLEIC acids
Subjects
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 24
- Issue :
- 5-7
- Database :
- Complementary Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 18909367
- Full Text :
- https://doi.org/10.1081/NCN-200060070