Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint.

Authors :: Holt, Sarah V.
Vergnolle, Mailys A. S.
Hussein, Deema
Wozniak, Marcin J.
Allan, Victoria J.
Taylor, Stephen S.
Source :: Journal of Cell Science; 10/15/2005, Vol. 118 Issue 20, p4889-4900, 12p
Publication Year :: 2005
Abstract: Discusses research being done on centromere protein-F (Cenp-F). Reference to a study by Sara V. Holt and colleagues, published in a 2005 issue of the "Journal of Cell Science"; Purpose of farnesylating Cenp-F; Implications of repressing Cenp-F by RNA interference.

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