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Large-scale studies of the association between variation at the TNF/ LTA locus and susceptibility to type 2 diabetes.
- Source :
- Diabetologia; Oct2005, Vol. 48 Issue 10, p2013-2017, 5p, 3 Charts
- Publication Year :
- 2005
-
Abstract
- Aims/hypothesis: The proinflammatory cytokine TNF-α has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-α (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes. The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources. Materials and methods: The G-308A and G-238A TNF promoter variants and the LTA T60N polymorphism were genotyped in two UK case samples that were ascertained for positive family history and/or early onset of type 2 diabetes (combined n=858) and in 1,257 ethnically matched controls. Results: There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran —Mantel—Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16). Conclusions/interpretation: The present study, one of the largest association analyses yet reported at this locus, provides no evidence that the specific TNF or LTA variants examined influence susceptibility to type 2 diabetes. More comprehensive studies of the TNF/LTA locus in substantially larger sample sets are required to establish whether genome sequence variation at this locus truly influences susceptibility to type 2 diabetes. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 2 diabetes
TUMOR necrosis factors
DIABETES
CYTOKINES
GLYCOPROTEINS
ENDOCRINOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 0012186X
- Volume :
- 48
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 18506566
- Full Text :
- https://doi.org/10.1007/s00125-005-1902-4