No positive association between adrenergic receptor variants of α2cDel322–325, β1Ser49, β1Arg389 and the risk for heart failure in the Japanese population.

Aims We investigated the correlation of adrenergic receptor polymorphisms, α_2cDel322–325, β₁Ser49Gly and β₁Arg389Gly, with the risk of heart failure in the Japanese population. Methods These polymorphisms were analysed by polymerase chain reaction-restriction fragment length polymorphism in patients with chronic heart failure due to idiopathic dilated cardiomyopathy (DCM) and compared with the control group. Results There were no differences or any trends in the allele and genotype frequencies of the β₁Ser49Gly and β₁Arg389Gly polymorphisms. The allele frequency of the α_2cDel322–325 variant was lower in patients than in controls (0.11 vs. 0.04, P = 0.011 < 0.017, by Bonferroni correction), while the genotype frequency just failed to reach significance ( P = 0.022 > 0.017, by Bonferroni correction). Conclusions In this population, the variants β₁Ser49, β₁Arg389, and α_2cDel322–325 do not appear to be risk factors for chronic heart failure due to DCM. The α_2cDel322–325 variant may in fact confer some protection. [ABSTRACT FROM AUTHOR]