Diagnosis of Intraductal Biliary Lesions: Towards Greater Accuracy and Safety.

The article discusses the challenges in diagnosing intraductal biliary lesions and the importance of accurate differentiation between benign and malignant cases. Various methods, such as endoscopic retrograde cholangiopancreatography (ERCP)-guided brush cytology and peroral cholangioscopy-guided biopsy, are explored for tissue diagnosis. A novel tapered-tip sheath system is introduced as a more effective and safer method for biliary lesion tissue sampling, showing promising results in terms of diagnostic efficacy and procedural safety. However, further validation through multicenter studies is needed to ensure broader applicability and acceptance in clinical practice. [Extracted from the article]