Back to Search Start Over

Diagnostic performance of tomosynthesis plus synthetic mammography versus full‐field digital mammography with or without tomosynthesis in breast cancer screening: A systematic review and meta‐analysis.

Authors :
Hamad, Wasim
Michell, Michael J.
Myles, Jonathan P.
Gilbert, Fiona J.
Chen, Yan
Jin, Huajie
Loveland, John
Halling‐Brown, Mark
Satchithananda, Keshthra
Morel, Juliet
Wasan, Rema
Taylor, Caroline
Sharma, Nisha
Valencia, Alexandra
Teh, Will
Majid, Faisal
De Visser, Ronald M
Iqbal, Asif
Duffy, Stephen W.
Source :
International Journal of Cancer; Mar2025, Vol. 156 Issue 5, p969-979, 11p
Publication Year :
2025

Abstract

Digital breast tomosynthesis (DBT) with full‐field digital mammography (FFDM) exposes women to a higher radiation dose. A synthetic 2D mammogram (S2D) is a two‐dimensional image constructed from DBT. We aim to evaluate the S2D performance when used alone or combined with DBT compared to FFDM alone or with DBT. Studies were included if they recruited screening participants and reported on S2D performance. Studies were excluded if they included symptomatic patients, imaging was for diagnostic purposes, or if participants had a breast cancer history. Meta‐analyses for cancer detection rates (CDR) and Specificities were conducted where available. Differences in the performance of imaging modalities were calculated within individual studies, and these were pooled by meta‐analysis. Out of 3241 records identified, 17 studies were included in the review and 13 in the meta‐analysis. The estimated combined difference in CDRs per thousand among individual studies that reported on DBT plus S2D vs. FFDM and those reporting on DBT plus S2D versus DBT plus FFDM was 2.03 (95% CI 0.81–3.25) and − 0.15 (95% CI −1.17 to 0.86), respectively. The estimated difference in percent specificities was 1.13 (95% CI −0.06 to 2.31) in studies comparing DBT plus S2D and FFDM. In studies comparing DBT plus S2D and DBT plus FFDM, the estimated difference in specificities was 1.08 (95% CI 0.59–1.56). DBT plus S2D showed comparable accuracy to FFDM plus DPT and improved cancer detection to FFDM alone. Integrating S2D with DBT in breast cancer screening is safe and preserves performance. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00207136
Volume :
156
Issue :
5
Database :
Complementary Index
Journal :
International Journal of Cancer
Publication Type :
Academic Journal
Accession number :
182078360
Full Text :
https://doi.org/10.1002/ijc.35217