Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease.

The article discusses the formation of glomerular crescents in autoimmune kidney diseases such as ANCA-associated vasculitis, anti-GBM, and lupus nephritis, which can lead to kidney failure. Through spatial transcriptomics analysis of patient samples, researchers found that immune cells infiltrate the glomerular compartment early on, followed by increases in adaptive immune cells in periglomerular regions. The study highlights the role of intercellular signaling between immune and renal cells, specifically PDGF and TGF-{beta} signaling, in driving glomerular crescent formation and sclerosis across different autoimmune kidney diseases. [Extracted from the article]