Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder.

Patients with major depressive disorder (MDD) and borderline personality disorder (BPD) are reported to have disrupted autobiographical memory (AM). Using functional magnetic resonance imaging we investigated behavioral and neural processing of the recall of emotional (sad and happy) memories in 30 MDD, 18 BPD, and 34 healthy control (HC) unmedicated women. The behavioral results showed that the MDD group experienced more sadness than the HC after the sad recall, while BPD participants experienced less happiness than HC after the happy recall. The fMRI results for sad AMs, compared to happy AMs, elicited greater activation in multiple brain regions (i.e., medial prefrontal cortex, posterior cingulate cortex, insula) linked to self-related information, emotional processing, and semantic recollection across all groups. Functional connectivity analysis revealed a significant main effect of group between the occipital cortex and precuneus and between occipital cortex and posterior cingulate cortex. The effect was driven by stronger connectivity between the occipital cortex and precuneus in the clinical groups taken together than in the HC. Our results suggest a need for stronger coordination between visual imagery and contextual recall for vivid memory retrieval in these clinical groups. [ABSTRACT FROM AUTHOR]