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Sonogenetics in the Treatment of Chronic Diseases: A New Method for Cell Regulation.

Authors :
Zhu, Mingrui
Fang, Yan
Sun, Yikang
Li, Shaoyue
Yu, Jifeng
Xiong, Bing
Wen, Congjian
Zhou, Boyang
Huang, Bin
Yin, Haohao
Xu, Huixiong
Source :
Advanced Science; 12/26/2024, Vol. 11 Issue 48, p1-23, 23p
Publication Year :
2024

Abstract

Sonogenetics is an innovative technology that integrates ultrasound with genetic editing to precisely modulate cellular activities in a nonā€invasive manner. This method entails introducing and activating mechanosensitive channels on the cell membrane of specific cells using gene delivery vectors. When exposed to ultrasound, these channels can be manipulated to open or close, thereby impacting cellular functions. Sonogenetics is currently being used extensively in the treatment of various chronic diseases, including Parkinson's disease, vision restoration, and cancer therapy. This paper provides a comprehensive review of key components of sonogenetics and focuses on evaluating its prospects and potential challenges in the treatment of chronic disease. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
21983844
Volume :
11
Issue :
48
Database :
Complementary Index
Journal :
Advanced Science
Publication Type :
Academic Journal
Accession number :
181922051
Full Text :
https://doi.org/10.1002/advs.202407373