Comparative Efficacy of Orbital Atherectomy and Intravascular Lithotripsy in the Treatment of Calcified Coronary Nodules. The ORBIT-SHOCK Pilot Study.

The ORBIT-SHOCK pilot study is a clinical trial comparing the efficacy of orbital atherectomy (OA) and intravascular lithotripsy (IVL) in treating calcified coronary nodules (CN) in patients with atherosclerotic coronary artery disease. Patients will be randomized to undergo lesion preparation with OA or IVL in a 1:1 ratio, aiming to compare PCI outcomes and adverse event incidence. The study will monitor stent expansion, procedural success, strategy success, calcium nodule modification, and adverse clinical events over 12 months post-procedure. The trial is not yet recruiting and will enroll 50 participants in Spain, with a completion date of December 2026. [Extracted from the article]