French National Institute of Health and Medical Research (INSERM) Reports Findings in Leukemia (Progressive chromatin rewiring by ETO2::GLIS2 revealed in a human iPSC model of pediatric leukemia initiation).

A study conducted by the French National Institute of Health and Medical Research (INSERM) focused on pediatric acute myeloid leukemia, specifically examining the ETO2::GLIS2 fusion oncogene. The research utilized human induced pluripotent stem cells (iPSC) to model the progression of leukemia, highlighting the role of the osteogenic homeobox factor DLX3 in chromatin changes and leukemogenesis. The findings suggest that DLX3 is a crucial factor in the early stages of leukemia initiation driven by the ETO2::GLIS2 fusion oncogene. This research has been peer-reviewed and offers valuable insights into the mechanisms underlying pediatric leukemia. [Extracted from the article]