King Abdullah University of Science and Technology (KAUST) Researcher Adds New Data to Research in Disease Progression (Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and...).

Researchers at King Abdullah University of Science and Technology (KAUST) in Saudi Arabia conducted a study on disease progression in multiple myeloma (MM), a complex malignancy affecting plasma cells in the bone marrow. The study focused on the genetic and epigenetic changes that occur as the disease transitions from asymptomatic stages to active MM. By analyzing gene expression, chromatin accessibility, and histone marks, the researchers identified key regulatory elements and pathways driving MM pathogenesis, aiming to improve early screening and develop targeted therapies. The study underscores the importance of integrated multi-omics approaches in understanding the complex regulatory networks of MM. [Extracted from the article]