Reports Outline Acute Lymphoblastic Leukemia Study Results from Kusuma School of Biological Science (A Pre-6 Acute Lymphoblastic Leukemia Cell Line Model Reveals the Mechanism of Thalidomide Therapy-related 6-cell Leukemogenesis).

A study conducted at the Kusuma School of Biological Science in New Delhi, India, focused on the mechanism of thalidomide therapy-related B cell acute lymphoblastic leukemia (B-ALL). The research revealed that thalidomide treatment of B cell lines increased CD34 expression and fibronectin adhesion, resembling the effects of Ikzf1 loss of function mutations in B-ALL. The study concluded that thalidomide alters the chromatin occupancy of IKZF1 at key B-cell lineage transcription factors, leading to a persistent block in B-cell differentiation. [Extracted from the article]