Osaka University Researcher Publishes New Study Findings on Amino Acids (Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell...).

A recent study conducted at Osaka University in Japan introduced a novel choline-deficient and 0.1%-methionine-added high-fat diet that induces metabolic-dysfunction-associated steatohepatitis (MASH) in mice without severe body weight loss. The research aimed to create a more accurate animal model for human MASH to evaluate potential drug efficacy. The study found that the MASH diet accelerated lipid accumulation and liver fibrosis, with immune cell infiltration potentially contributing to the initiation of MASH pathogenesis. This model could serve as a valuable pre-clinical tool for developing treatments for human MASH. [Extracted from the article]