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CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages
- Source :
- FEMS Immunology & Medical Microbiology; Sep2005, Vol. 45 Issue 2, p303-310, 8p
- Publication Year :
- 2005
-
Abstract
- Abstract: Immunostimulatory DNA sequences and their synthetic oligonucleotide analogs (CpG-ODN) activate innate immunity and can stimulate antibacterial effects against numerous intracellular pathogens. While it has been shown previously that CpG-ODN inhibit growth of Mycobacterium avium in murine and human macrophages, we now report that Mycobacterium tuberculosis growth can be inhibited by CpG-ODN treatment of human monocyte-derived macrophages (hMDM). This inhibitory effect was reversed by IFN-γ, which has been shown repeatedly to enhance the growth of virulent M. tuberculosis in cultured hMDM. The antibacterial effect of CpG-ODN in human macrophages was specific for M. tuberculosis when compared to other intracellular pathogens including Listeria monocytogenes and Salmonella enterica serovar Dublin. These data indicate that CpG-ODN can improve the ability of hMDM to contain growth of virulent M. tuberculosis. [Copyright &y& Elsevier]
- Subjects :
- OLIGONUCLEOTIDES
NATURAL immunity
MYCOBACTERIAL diseases
MACROPHAGES
Subjects
Details
- Language :
- English
- ISSN :
- 09288244
- Volume :
- 45
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- FEMS Immunology & Medical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 18165892
- Full Text :
- https://doi.org/10.1016/j.femsim.2005.05.007