Synthesis of [14C] quincetone.

The water-soluble fullerene derivative C₆₀(OH)_x was radiolabeled with ⁶⁷GaCl₃. The labeling yields were determined by radio-PLC. The effects of pH, reaction time, temperature and the amount of C₆₀(OH)_x on the labeling yields were studied. The stability of ⁶⁷Ga-C₆₀(OH)_x was also examined. The results showed that the labeling yields could reach 97% under the best labeling conditions and the radiochemical purity of ⁶⁷Ga-C₆₀(OH)_x solution kept at 37 °C remained at 88% after 212 hours. The biodistribution studies of ⁶⁷Ga-C₆₀(OH)_x in mice showed a high localization of ⁶⁷Ga-C₆₀(OH)_x in the bone marrow, bone, liver and spleen with slow clearance and a negligible accumulation in the blood. These data suggest that the water-soluble C₆₀(OH)_x, having the same properties as microcolloids, may be used as a carrier of drug system for lymphatic targeting. [ABSTRACT FROM AUTHOR]