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Ferric ions crosslinked hyaluronic acid beads: potentials for drug delivery use.

Ferric ions crosslinked hyaluronic acid beads: potentials for drug delivery use.

Authors :
Mashaqbeh, Hadeia
Obaidat, Rana
Rezigue, Meriem
Omari, Derar
Shakhatreh, Ghyda'a
Source :
Drug Development & Industrial Pharmacy; Oct2024, Vol. 50 Issue 10, p865-877, 13p
Publication Year :
2024

Abstract

Introduction and purpose: Despite the attractive properties of hyaluronic acid (HA), The preparation of HA beads is still challenging. This article reports the preparation of pH-sensitive gel HA beads. The ionic gelation method was used to prepare the HA gel beads using ferric ions. This cross-linking type is based on forming coordination bonds, which enhance the mechanical properties of the prepared beads. Methods: The developed beads were characterized using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Scanning electron microscopy (SEM) examined the bead's morphology. Furthermore, the potential of HA gel beads as an oral drug delivery system was investigated using metformin as a hydrophilic model drug. The entrapment efficiency and in vitro, release, and release kinetics were evaluated. The crosslinking density and HA concentration effect on drug release and bead swelling capacity under pH 1.2 and 7.4 were also investigated. Results: The entrapment efficiency of metformin in HA beads was found to be 79.56 ± 3.89%. FTIR analysis indicated the ionic interaction between ferric ions and the carboxylic groups on the HA molecule. At the same time, there was no substantial interaction between metformin and the polymeric bead. Morphological evaluation and DSC analysis suggested the successful incorporation of metformin within the beads. The in vitro drug release evaluation showed pH-dependent extended release where the release kinetics followed the first-order mathematical model. Conclusions: This study provides a value-added formulation with the potential for drug delivery use, which can be further investigated for biomedical applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03639045
Volume :
50
Issue :
10
Database :
Complementary Index
Journal :
Drug Development & Industrial Pharmacy
Publication Type :
Academic Journal
Accession number :
181256979
Full Text :
https://doi.org/10.1080/03639045.2024.2422497