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Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces.

Authors :
Wang, Hao
Gong, Feirong
Liu, Jiajie
Xiang, Lanlan
Hu, Yanfen
Che, Wenchen
Li, Ran
Yang, Sisi
Zhuang, Qixin
Teng, Xin
Source :
Bioengineering (Basel); Nov2024, Vol. 11 Issue 11, p1078, 15p
Publication Year :
2024

Abstract

Docetaxel has exhibited excellent therapeutic effects in cancer treatment; however, its hydrophobicity, short blood circulation time, and high blood toxicity restrict its clinical application. The use of mPEG-PLA micelles to deliver docetaxel into the body has been verified as an effective approach to enhance its therapeutic efficacy. However, mPEG-PLA micelles are easily disassembled in the bloodstream, which can easily lead to premature drug release. To broaden the application scenarios of mPEG PLA micelles, we utilized the π–π stacking effect as an intermolecular force to design a novel mPEG-PLA-Lys(Fmoc) micelle to enhance the blood stability and permeability of drug-loaded micelles. The result showed that drug-loaded micelles for injection did not alter the tissue selectivity of docetaxel. Intravenous injection of the micelles in nude mice showed better antitumor efficacy than docetaxel injection and tumor recurrence rate is 0%, which is significantly lower than that of docetaxel injection (100%). The micelles designed by this research institute are anticipated to improve the clinical therapeutic effect of docetaxel. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23065354
Volume :
11
Issue :
11
Database :
Complementary Index
Journal :
Bioengineering (Basel)
Publication Type :
Academic Journal
Accession number :
181168501
Full Text :
https://doi.org/10.3390/bioengineering11111078