The Optical Forces and Torques Exerted by Airy Light-Sheet on Magnetic Particles Utilized for Targeted Drug Delivery.

The remarkable properties of magnetic nanostructures have sparked considerable interest within the biomedical domain, owing to their potential for diverse applications. In targeted drug delivery systems, therapeutic molecules can be loaded onto magnetic nanocarriers and precisely guided and released within the body with the assistance of an externally applied magnetic field. However, conventional external magnetic fields generated by permanent magnets or electromagnets are limited by finite magnetic field gradients, shallow penetration depths, and low precision. The novel structured light field known as the Airy light-sheet possesses unique characteristics such as non-diffraction, self-healing, and self-acceleration, which can potentially overcome the limitations of traditional magnetic fields to some extent. While existing studies have primarily focused on the manipulation of dielectric particles by Airy light-sheet, comprehensive analyses exploring the intricate interplay between Airy light-sheet and magnetic nanostructures are currently lacking in the literature, with only preliminary theoretical discussions available. This study systematically explores the mechanical response of magnetic spherical particles under the influence of Airy light-sheet, including radiation forces and spin torques. Furthermore, we provide an in-depth analysis of the effects of particle size, permittivity, permeability, and incident light-sheet parameters on the mechanical effects. Our research findings not only offer new theoretical guidance and practical references for the application of magnetic nanoparticles in biomedicine but also provide valuable insights for the manipulation of other types of micro/nanoparticles using structured light fields. [ABSTRACT FROM AUTHOR]