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Clinical, magnetic resonance imaging and histopathological findings of a congenital hypomyelinating leukodystrophy in a Holstein Friesian calf.

Clinical, magnetic resonance imaging and histopathological findings of a congenital hypomyelinating leukodystrophy in a Holstein Friesian calf.

Authors :
Planas, Carles
van de Poel, Nyke C.
Dimmendaal, Sanne
Weerts, Erik
Hut, Peter
Santifort, Koen
Veraa, Stefanie
Source :
Veterinary Record Case Reports; Dec2024, Vol. 12 Issue 4, p1-10, 10p
Publication Year :
2024

Abstract

A 12‐day‐old, male Holstein Friesian calf was presented to the hospital due to progressive ataxia and tremors since birth. A diffuse central nervous system disorder primarily affecting white matter was suspected based on clinical neurological examination. Blood tests were unremarkable, except for positive serology for Schmallenberg virus. Magnetic resonance imaging of the brain demonstrated severe, diffuse abnormalities primarily affecting the white matter regions of the encephalon and cranial cervical spinal cord, consistent with leukoencephalomyelopathy. Euthanasia was performed at 8 weeks of age after no clinical improvement. A postmortem examination was performed. Histopathological examination of the central nervous system revealed changes compatible with hypomyelinating leukodystrophy, with no signs of infectious agents observed. The disorder was considered most likely to be hereditary, as Schmallenberg virus infections during pregnancy in cattle have not been reported to result in such clinical, magnetic resonance imaging or histopathological findings, and no viral genomic material was identified with polymerase chain reaction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20526121
Volume :
12
Issue :
4
Database :
Complementary Index
Journal :
Veterinary Record Case Reports
Publication Type :
Academic Journal
Accession number :
181153931
Full Text :
https://doi.org/10.1002/vrc2.954