CD40 ligation-induced ERK activation promotes autophagy which leads to enhanced radiosensitivity in cervical carcinoma cells.

The article discusses the role of CD40 ligation in promoting autophagy in cervical carcinoma cells, leading to enhanced radiosensitivity. CD40, a member of the TNF receptor superfamily, is known to play a crucial role in both the immune system and tumor progression. The study found that CD40 ligation induces autophagosome formation and flux in cervical cancer cells, with ERK contributing to this process. These findings suggest a potential link between the CD40 pathway, autophagy, and radiotherapy in cervical cancer treatment. [Extracted from the article]