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An Update on the Role of Renal Artery Denervation in the Treatment of Hypertension.

Authors :
Mewaldt, Christian
Crawford, Emily
Cluett, Jennifer
Arvanitis, Lorenzo V.
Kentoffio, Katie
Secemsky, Eric A.
Krawisz, Anna K.
Source :
Current Treatment Options in Cardiovascular Medicine; 2025, Vol. 27 Issue 1, p1-13, 13p
Publication Year :
2025

Abstract

Purpose of Review: This review provides a practical, evidence-based summary of the physiology, major trial data and clinical role of renal denervation in the treatment of hypertension. Recent Findings: The cornerstone of hypertension therapy remains anti-hypertensive medications although this strategy has significant limitations with poor rates of blood pressure control for most patients. Renal denervation was designed to bypass concerns about medication adherence and provide an "always-on" treatment. Recent trial data and meta-analyses are presented demonstrating a modest, although heterogeneous, response to renal denervation which led to the treatment's recent FDA approval. Improvements in catheter design and renal artery treatment strategy may underlie the improved clinical response to denervation in more recent trials. Summary: Hypertension centers involving multi-disciplinary care teams are equipped to provide patients with advanced diagnostic testing for secondary hypertension, comprehensive non-invasive management strategies and invasive renal denervation to address hypertension. Early referral for patients with uncontrolled hypertension can provide patients with nuanced conservative and interventional options which have the potential to improve hypertension related morbidity and mortality. Future studies are needed to identify which patients are most likely to respond to renal denervation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10928464
Volume :
27
Issue :
1
Database :
Complementary Index
Journal :
Current Treatment Options in Cardiovascular Medicine
Publication Type :
Academic Journal
Accession number :
181133019
Full Text :
https://doi.org/10.1007/s11936-024-01063-1