Analysis of causal relationship between blood metabolites and prostate cancer by two-sample Mendelian randomization.

Objective: To investigate the causal relationship between blood metabolite levels and the occurrence of prostate cancer by using two-sample Mendelian randomization method. Methods: Pooled data from public databases for genome-wide association analyses of blood metabolites and prostate cancer were selected, and inverse variance weighting (IVW) was used as the primary method for estimating the causal effects, while heterogeneity tests, gene multiplicity tests and sensitivity analyses were performed to assess the stability and reliability of the results. Results: A total of six known metabolites were found to potentially increase the risk of prostate cancer development (P < 0.05), namely fructose, allantoin, 5-hydroxytryptophan, potassium ketoisocaproate, glycyltryptophan, and 1-heptadecanoyl-glycerol-3-phosphorylcholine, with no heterogeneity or genetic pleiotropy found. Conclusion: Six known blood metabolites may be potential risk factors for prostate cancer development in European populations. [ABSTRACT FROM AUTHOR]