Association of TyG index with aortic valve calcification in valvular heart disease patients.

Background In recent years, triglyceride glucose (TyG) index, as a popular metabolic index, has been proposed as an alternative index of insulin resistance, and it has been proved to be associated with many cardiovascular diseases, but the relationship between it and aortic valve calcification is still unknown. Methods A total of 450 aortic valve disease patients were enrolled in this study, including 361 patients with aortic valve calcification (AVC) (calcification group) and 89 patients without (control group). According to the severity of AVC, patients with AVC included severe calcification, moderate calcification and low calcification. The TyG index was calculated based on fasting triglyceride and fasting blood glucose levels. Results The TyG index in the calcification group was significantly higher than that in the control group (P  < .05), and with the increase of the degree of calcification, the TyG index showed an increasing trend. The univariate and multivariate logistic regression analysis showed TyG index has a high predictive value for the presence of AVC (OR (95% CI): 1.743 (1.036–2.933)) and severe AVC (OR (95% CI): 1.608 (1.143–2.262)). In assessing the predictive value of the TyG index distribution width for AVC, with the first quartile as a reference, the last quartile of the TyG index had significant predictive value for the presence of AVC and severe AVC. Conclusions TyG index was significantly associated with the presence and severity of AVC, suggesting that TyG index may be a valid predictor of AVC. Key messages What is already known on this topic. Triglyceride glucose (TyG) index is a reliable and specific index of insulin sensitivity in vivo. TyG index is closely related to various traditional risk factors for cardiovascular disease. What this study adds. TyG index was significantly associated with the presence and severity of AVC. How this study might affect research, practice or policy. This study lays the groundwork for investigating the mechanism underlying the association between the TyG index and AVC, and proposes the potential of attenuating the progression of AVC by judiciously reducing the TyG index in patients. [ABSTRACT FROM AUTHOR]