Back to Search Start Over

Epigenetics and alternative splicing in cancer: old enemies, new perspectives.

Authors :
Pandkar, Madhura R.
Shukla, Sanjeev
Source :
Biochemical Journal; Nov2024, Vol. 481 Issue 21, p1497-1518, 22p
Publication Year :
2024

Abstract

In recent years, significant strides in both conceptual understanding and technological capabilities have bolstered our comprehension of the factors underpinning cancer initiation and progression. While substantial insights have unraveled the molecular mechanisms driving carcinogenesis, there has been an overshadowing of the critical contribution made by epigenetic pathways, which works in concert with genetics. Mounting evidence demonstrates cancer as a complex interplay between genetics and epigenetics. Notably, epigenetic elements play a pivotal role in governing alternative pre-mRNA splicing, a primary contributor to protein diversity. In this review, we have provided detailed insights into the bidirectional communication between epigenetic modifiers and alternative splicing, providing examples of specific genes and isoforms affected. Notably, succinct discussion on targeting epigenetic regulators and the potential of the emerging field of epigenome editing to modulate splicing patterns is also presented. In summary, this review offers valuable insights into the intricate interplay between epigenetics and alternative splicing in cancer, paving the way for novel approaches to understanding and targeting this critical process. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02646021
Volume :
481
Issue :
21
Database :
Complementary Index
Journal :
Biochemical Journal
Publication Type :
Academic Journal
Accession number :
181001035
Full Text :
https://doi.org/10.1042/BCJ20240221